Targeting the cancer microenvironment

Researchers demonstrate that a novel biochemical checkpoint in these cells can inhibit the growth of cells that support cancer cell growth. Researchers discover a novel checkpoint in immune cells with the potential to treat the cancer cell microenvironment The recognition of bacterial infections or foreign substances is mediated and controlled by the human immune system. This innate and adaptive immune system comprises the most important metabolic and cellulare processes to fight against infections and other diseases. Paradoxically, this immune system is also involved in the development of systemic diseases and cancer. Therefore it is of utmost importance to further understand fundamental biochemical processes involved in the cellular reactions of the immune system which can lead directly to novel therapies against systemic diseases and cancer. The enormeous complexity of the immune system comprises different cell types. Two types, M1- and M2-type macrophages are involved in inflammatory defense mechanisms (M1) but also healing processes (M2).