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A recent study led by MedUni Vienna provides new insights into the mechanisms of coagulation in persons with haemophilia A, the most common form of haemophilia. The research team was able to show that saliva contains special vesicles that trigger rapid coagulation of the blood of haemophilic patients.

Researchers from the Vienna Lung Transplant Program of MedUni Vienna and University Hospital Vienna have published the first prospective, randomized and controlled study on the use of extracorporeal photopheresis (ECP) in lung transplantation in the renowned European Respiratory Journal. The findings could significantly change the standard procedure for rejection reactions after lung transplants.

Creutzfeldt-Jakob disease (CJD) is a very rare neurodegenerative disease that is fatal within a few months and still poses many questions to scientists. To date, no specific symptoms are known that precede the onset of the disease. A suspected diagnosis can usually be made on the basis of a particular combination of symptoms and examination findings, but can only be confirmed after the death of the affected person.

A MedUni Vienna study has identified a new approach to the drug treatment of metabolic liver diseases. In an experimental study, pharmacological inhibition of an enzyme that plays a central role in fat metabolism promoted liver health reduced liver fat, inflammation and fibrotic remodeling (connective tissue scarring).

Diffuse hemispheric glioma (DHG) is a brain tumor in children, adolescents and young adults with an average survival prognosis of less than two years and limited treatment options. A research team from MedUni Vienna and University Hospital Vienna has identified increased stress through targeted DNA breaks with simultaneous inhibition of DNA repair in the tumor cell as a promising therapeutic approach.

The Ignaz Semmelweis Institute will start work at the beginning of 2025.

The black box of the human brain is beginning to open. Although animal models are crucial for our understanding of the mammalian brain, the less frequently collected human data reveal important peculiarities. In a recent paper published in the journal Cell, a team led by the Institute of Science and Technology Austria (ISTA) and the Medical University of Vienna has shed light on the human hippocampal region CA3, which is central to memory storage.

The black box of the human brain is beginning to open. Although animal models are crucial for our understanding of the mammalian brain, the less frequently collected human data reveal important peculiarities. In a recent paper published in the journal Cell, a team led by the Institute of Science and Technology Austria (ISTA) and the Medical University of Vienna has shed light on the human hippocampal region CA3, which is central to memory storage.

ISTA biologists team up with neurosurgeons to unravel the human brain's specificities The black box of the human brain is starting to crack open. Although animal models are instrumental in shaping our understanding of the mammalian brain, scarce human data is uncovering important specificities. In a paper published in Cell , a team led by the Jonas group at the Institute of Science and Technology Austria (ISTA) and neurosurgeons from the Medical University of Vienna shed light on the human hippocampal CA3 region, central for memory storage.

As much as targeted therapy using so-called EGFR inhibitors has proven its worth for various types of tumours, possible side effects can be very stressful for patients. Scarring alopecia - permanent hair loss that can only be delayed but not reversed - is particularly cause for concern. Researchers at MedUni Vienna have now identified JAK inhibitors as active substances that can reactivate hair growth.

Advanced liver disease is the second most common cause of lost working years, as it disproportionately affects young patients. Possible complications of these diseases can often be traced back to high blood pressure in the blood circulation of the liver - portal hypertension. Under the leadership of Mattias Mandorfer from the Clinical Division of Gastroenterology and Hepatology at MedUni Vienna and University Hospital Vienna, the NICER model has now been developed, which can calculate the percentage probability of the presence of portal hypertension without an invasive procedure.

When women are pregnant and nurse their babies, their bodies change and various organs, such as the breasts or the immune system, are adapted to ensure the health of both mother and child. This happens throughout evolution in all mammals. An international research team led by Josef Penninger and Masahiro Onji, Medical University of Vienna, now reports the surprising finding that the intestine also changes completely in pregnant and nursing females, resulting in a doubling of the intestinal surface area and a striking structural reorganisation.

A screening study carried out at MedUni Vienna has shown that the rare but dangerous infection with the hepatitis D virus remained often undetected. Seamless testing at University Hospital Vienna for the presence of a hepatitis D infection increases the diagnosis rate of this now treatable disease. The results of It is estimated that more than 40,000 people in Austria are chronically infected with the hepatitis B virus.

ISTA scientists use harmless viruses to investigate the nervous system in frogs Amphibians hold a significant place in evolution, representing the transition from aquatic to terrestrial lifestyles. They are crucial for understanding the brain and spinal cord of tetrapods-animals with four limbs, including humans.

Secondary lymphoid organs are specialised structures in the body in which immune cells multiply and develop to respond to new pathogens such as viruses and bacteria. An international team led by Kaan Boztug (St. Anna Children's Cancer Research, MedUni Vienna, CeMM) has now been able to identify a completely new form of a rare disease that provides a better understanding of the importance of these structures for the human immune system.

A recent study by the Medical University of Vienna shows that adolescents with a history of non-suicidal self-injurious behaviour (NSSI) show increased attention to images of self-harm on social media. This attention bias - the increased and faster fixation on such content - increases the urge to self-harm.

Researchers at the University of Vienna develop gut-stable oxytocin analogues for targeted pain treatment of chronic abdominal pain A research team at the University of Vienna, led by medicinal chemist Markus Muttenthaler, has developed a new class of oral peptide therapeutic leads for treating chronic abdominal pain.

Disruption of the microbial community favours pathogens in the gut In a groundbreaking new study, conducted within the framework of the FWF-funded Cluster of Excellence "Microbiomes drive Planetary Health", scientists from the University of Vienna, in collaboration with the University of Southampton, Aalborg University and Boston University, have revealed that the widely prescribed Parkinson's disease drug entacapone significantly disrupts the human gut microbiome by inducing iron deficiency.

In a study recently published in "Nature Communications", researchers from MedUni Vienna and the Centre National de Recherche Scientifique (CNRS) in Paris show how dimerization of the RNA editing enzyme ADAR selectively alters its specificity at certain sequences. The knowledge gained opens up new possibilities to modulate the functions of ADAR1 via its dimerization for therapeutic purposes in autoimmune diseases or cancer.

A large number of effective drugs are currently available for the treatment of rheumatoid arthritis, but until now there has been a lack of suitable strategies for choosing the best possible therapy for individual patients. In a comprehensive scientific review led by rheumatologist Daniel Aletaha, Head of the Department of Medicine III at MedUni Vienna, a model has now been developed that focuses on the individual needs of patients and their health situation.