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The novel glycopeptide saarvienin A is highly effective against resistant pathogens An international team of researchers, led by the University of Vienna and the Helmholtz Institute for Pharmaceutical Research Saarland, has discovered saarvienin A , a new type of glycopeptide antibiotic. Their findings, now published in Angewandte Chemie International Edition , introduce a compound with strong activity against highly resistant bacterial strains.

Voltage-gated calcium channels are associated with numerous diseases. A new research group led by Nadine Ortner from the Institute of Pharmacy at the University of Innsbruck is now focusing on gene mutations that impair the function of a specific channel subtype known as CaV1. The five-person interdisciplinary team is funded by the Austrian Science Fund (FWF) with 1.64 million euros.

Brain metastases often occur as a result of advanced cancer and, despite medical innovations, are still associated with a poor prognosis. Now, an international expert committee led by the Medical University of Vienna and the Ludwig Maximilian University Hospital (LMU) in Munich has taken an important step towards improving diagnostics and therapy monitoring.

An international team of scientists led by the Medical University of Vienna has identified similarities in the mechanisms of diabetes and cancer: as the researchers show, the protein PPAR', which is central to the regulation of metabolic processes, can also influence the growth of prostate cancer cells.

Concentrations as high as those by a busy road illustrate the importance of solutions Those who climb indoors are doing something for their health. But climbing shoes contain chemicals of concern that can enter the lungs of climbers through the abrasion of the soles. In a recent study, researchers from the University of Vienna and EPFL Lausanne have shown for the first time that high concentrations of potentially harmful chemicals from climbing shoe soles can be found in the air of bouldering gyms, in some cases higher than on a busy street.

Oral mucositis (OM) is an inflammation of the oral mucosa and is a common complication in patients following allogeneic stem cell transplantation. Although the percentage of those affected is around 76 percent, there are currently no strategies for risk assessment. A research team at MedUni Vienna has now comprehensively and systematically analysed the already known link between oral health and the risk of OM for the first time.

A recent study led by the Medical University of Vienna shows that the haematocrit value, i.e. the proportion of red blood cells in blood volume, has a direct influence on blood sugar levels. The researchers were able to show that an increase in the number of red blood cells directly causes a decrease in blood sugar.

Researchers identify the benefits of participating in art-viewing activities Simply looking at visual art, visiting a museum, or having art in your hospital room can enhance well-being, particularly repeated engagement, which can increase the meaning we feel in life, according to a new international study led by researchers from the University of Vienna.

Together with the company BRAVE Analytics, researchers at TU Graz have developed a method for detecting nanoplastics in liquids and determining their composition. Microplastics and the much smaller nanoplastics enter the human body in various ways, for example through food or the air we breathe. A large proportion is excreted, but a certain amount remains in organs, blood and other body fluids.

Multiple antibiotic resistance is auxiliary to bacterial fitness and adaptability Could a gene regulatory network in gut microbes have evolved its elaborate and tightly regulated molecular machinery only to pump out antibiotics indiscriminately? Researchers from the Institute of Science and Technology Austria (ISTA) show this is an auxiliary function.

First report of a new DNA marker outside of microbes, important for sperm function Could it be that one of only three known markers directly targeting the DNA does not exist outside the realm of microbes? Now, researchers led by Xiaoqi Feng at the Institute of Science and Technology Austria (ISTA) have demonstrated that this marker-N4-methylcytosine (4mC)-is essential for sperm development and maturation in the liverwort Marchantia polymorpha , a key organism in plant evolution.

Body signals such as heartbeat and breathing accompany us constantly, often unnoticed as background noise of our perception. Even in the earliest years of life, these signals are important as they contribute to the development of self-awareness and identity. However, until know little has been known about whether and how babies can perceive their own body signals.

A temporary bacterial infection of the skin can cause long-lasting changes in the immune system and increase allergic inflammation. This is the result of a study led by the Medical University of Vienna and the CeMM Research Center for Molecular Medicine, which has just been published in the leading journal "Science Immunology".

Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding developmental processes. While not exact replicas of human organs, they offer significant insights. The Siegert group at the Institute of Science and Technology Austria (ISTA) presents a new organoid model that reveals details of the developing nervous system's response to viral infections, such as Rubella.

This novel antibiotic activates an existing "suicide" mechanism in gonococci The increase of microbes resistant to antibiotics is a growing problem. These include, for example, Neisseria gonorrhoeae , a bacterium which causes gonorrhea. Researchers from the universities in Konstanz and Vienna discover a new class of antibiotic that selectively targets Neisseria gonorrhoeae.

A recent study on fish allergies has gained new insights into the reactivity to parvalbumins, the main allergens in fish. A research team from Karl Landsteiner University of Health Sciences and the Medical University of Vienna, together with international colleagues, examined the IgE reactivity to parvalbumins from 12 different freshwater fish species from Austria.

Pulmonary fibrosis is a severe, chronic disease that predominantly affects people at an advanced age. Since there are currently no specific treatments, lung transplantation often remains the only option to prolong the patient's life. A research team from MedUni Vienna has now discovered that an ageing immune system plays a significant role in the development and progression of the disease.

A research team from the Medical University of Vienna has investigated structural changes in kidneys of patients with hypertension and type 2 diabetes. The results show that high blood pressure can lead to abnormalities in the podocytes, specialised cells in the renal filter, even without other pre-existing conditions such as diabetes.

A research team from MedUni Vienna has gained new insights into the role of the immune system in allergic asthma. The study examined the molecular regulation of certain immune cells, known as pathogenic Th2 cells, which are involved in the development of allergic diseases and are responsible for persistent inflammation of the respiratory tract.

Although persons with haemophilia have nowadays reached a similar life expectancy as the general population in regions of the world with access to safe and effective therapies, little is known about the biological ageing process in the people with this congenital bleeding disorder. In a study recently published in the journal "Haematologica", researchers from the MedUni Vienna have now shown that people with haemophilia have a significantly increased biological age.