Studies demonstrated that trefoil factor peptides are locally produced to combat inflammation and injuries of the gastrointestinal tract by accelerating wound healing.
Studies demonstrated that trefoil factor peptides are locally produced to combat inflammation and injuries of the gastrointestinal tract by accelerating wound healing. Universität Wien) - Milestone for therapeutic development of peptides against gastrointestinal disorders The fascinating family of trefoil factor peptides brings hope to both research and industry to improve the treatment of chronic disorders such as Crohn's disease. For the first time, a team led by ERC awardee Markus Muttenthaler from the Faculty of Chemistry of the University of Vienna succeeded in the synthesis and folding of the peptide TFF1, a key player in mucosal protection and repair. Chemical synthesis of these gastrointestinal peptides is an important step towards a better understanding of their mode of action and therapeutic potential. The study was published in "Chemical Communications". The three known human trefoil factor family peptides TFF1, TFF2 and TFF3 are mainly produced by the gastrointestinal mucosa. Named after their trefoil-like folded structure, the molecules provide clinically intriguing properties.
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