New selective synthesis of all 1,4-dicarbonyl isomers from sulfoxides and selected important bioactive compounds featuring the 1,4-dicarbonyl motif
Chemists from the University of Vienna finally find a surprisingly simple reaction to make a family of bioactive molecules. Many natural products and drugs feature a so-called dicarbonyl motif - in certain cases however their preparation poses a challange to organic chemists. In their most recent work, Nuno Maulide and his coworkers from the University of Vienna present a new route for these molecules. They use oxidized sulfur compounds even though sulfur is not included in the final product. The results are now published in the prestigious journal "Science". To live up to mankind's challenges, we are in constant need for new molecules. New drugs need to be designed and tested, new materials prepared and this is the challenge faced by the organic chemist.
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