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The "Data" working group headed by Oliver Kimberger, Professor of Perioperative Information Management at MedUni Vienna's Department of Anesthesiology, Intensive Care Medicine and Pain Medicine, conducted a study to investigate the influence of artificial intelligence on doctors' covid triage decisions.

Sarcoidosis is an inflammatory disease in which immune cells form tissue nodules in various organs, which can drastically impair organ function. Now a MedUni Vienna research team led by Thomas Weichhart from the Center for Pathobiochemistry and Genetics has developed an animal model that replicates the development of the disease in the heart and can contribute to research into sarcoidosis.

A prediction model can be used to identify people affected by venous thromboembolism who have only a low risk of recurrence and may not require long-term blood thinning. The validity of this "Vienna Prediction Model" developed at MedUni Vienna has now been confirmed in a large-scale clinical study and the results have been published in the renowned European Heart Journal.

A team of researchers at the Medical University of Vienna has discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein called P-glycoprotein (P-gp). This discovery opens up new possibilities for delaying relapse and is particularly relevant for aggressive triple-negative breast cancer (TNBC), for which there are currently few effective treatments.

Up to 15 percent of children and five percent of adults are affected by the chronic inflammatory skin disease atopic dermatitis. Despite advanced therapy measures, the severe itching and eczema, especially on the elbows or knees, cause great distress to the patients. In the course of a study conducted at MedUni Wien a research team led by Wolfgang Weninger, Head of the Department of Dermatology, has discovered a new approach: bacteriophages, which colonize the skin as viral components of the microbiome and can drive the development of innovative atopic dermatitis therapies.

Small cell lung cancer accounts for about 15 percent of all diagnosed lung cancers and is still associated with a high mortality rate. SCLC tumours often develop resistance to chemotherapy and thus poor prognosis is due to tumour recurrence which occurs within only five to 14 months after initial diagnosis.

Autoimmune diseases are complex conditions whose causes are diverse and have not been fully elucidated to date. A research team at MedUni Vienna has now discovered an immunoregulatory protein that could be linked to the development of autoimmune diseases such as rheumatoid arthritis. -Rinl- is the name of the identified building block of the immune system, which may provide a new starting point for the development of immunomodulatory therapies.

Autoimmune diseases are complex illnesses, the causes of which are diverse and have not yet been fully explained. A research team at MedUni Vienna has now discovered an immunoregulatory protein that could be linked to the development of autoimmune diseases such as rheumatoid arthritis. The identified component of the immune system is called "Rinl", which could provide a new target for the development of immunomodulatory therapies.

People who are treated with TNF-α inhibitors for their autoimmune disease such as Crohn's disease or rheumatoid arthritis lose their vaccination protection significantly earlier than average. The mechanism underlying the early decrease in antibody levels has now been eludicated by a scientific team from MedUni Vienna.

T cells are an essential component of the immune system - they fight foreign structures such as bacteria and viruses or cancer-related changes in cells. This defense reaction requires energy. Scientists led by the St. Anna Children's Cancer Research Institute, MedUni Vienna and the Marmara University Istanbul have now shown for the first time that a defect in the gene for the transcription factor NFATC1 leads to an immune defect with a disruption of metabolism in T lymphocytes.

Researchers in Vienna have obtained the world's first gene sequences of the human roundworm from the Bronze Age, as well as the first gene sequences from prehistoric parasites in Austria. The analysis was conducted on human faeces from prehistoric miners in Hallstatt. The findings were published by a team from the Medical University Vienna, the Austrian Academy of Sciences (OeAW) and the Natural History Museum Vienna in the journal Nature Scientific Reports.

The cell nucleus is surrounded by a spherical double membrane called the nuclear envelope. Scientists have long been intrigued by how this envelope can be elastic enough to accommodate shape changes that cells experience as they move through tissues, but also rigid enough to maintain nuclear integrity.

Patients with localised prostate cancer have a good chance of survival, but mortality rates among those with advanced, metastatic forms of the condition remain high. Until now, the precise mechanism behind the spread of the tumour has not been fully explained. But an international research team headed by MedUni Vienna has succeeded in decoding the underlying cellular signal pathway and has carried out research using a common diabetes medication that could provide a new treatment option.

Scientists at Medical University Vienna/St. Anna Children's Cancer Research Institute and the Eberhard Karls University of Tübingen have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children. Crucially, stem cells from a parent provide children with a new immune system that responds much better to immunotherapies.

A research group led by Giulio Superti-Furga of the Institute of Pharmacology at the Medical University and the CeMM Research Center has developed a new method that makes it possible to specifically inhibit important lactate transporters associated with cancer and numerous other diseases. This could provide a new starting point for the treatment of cancer in particular.

Artificial intelligence (AI) is already being used to diagnose skin cancer, but it cannot (yet) keep pace with the complex decision-making of doctors in practice. An international research team led by Harald Kittler of MedUni Vienna has now explored a learning method in which greater accuracy in AI results can be achieved by incorporating human decision-making criteria.

Scientists from the Giulio Superti-Furga Lab at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, have developed a new method that allows the discovery of specific inhibitors of a lactate transporter associated with cancer and other disease areas. The compound identified in the assay system could provide a new starting point for cancer treatments.

Cancer is twice as likely to affect people experiencing homelessness (PEH) as members of the housed population. The disease is the second most common cause of death among PEH, a group that is underserved when it comes to medical care. At the same time, there is a lack of awareness and of structures for targeted cancer screening.

The new subtype has been characterised as part of an international collaboration with a research group from Luxembourg, opening up the prospect of a possible new therapeutic approach. Members of Helmut Dolznig's research group at MedUni Vienna's Center for Pathobiochemistry and Genetics played a key role in the research work, which was recently published in the renowned journal Nature Communications.

A research team from the Department of Medicine III at MedUni Vienna and University Hospital Vienna has conducted a large-scale study showing the important value of repeated liver assessments by a novel method that can significantly improve risk assessment in patients with chronic liver disease. The dynamics of regular measurements of liver stiffness indicate a personalised patient risk profile which enables the initiation of individualized treatment strategies.