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Results 1 - 9 of 9.


Pharmacology - Health - 09.02.2021
The therapeutic potential of peptides
The therapeutic potential of peptides
Currently there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis.

Life Sciences - Pharmacology - 14.12.2020
RNA basic building block produced biocatalytically for the first time
RNA basic building block produced biocatalytically for the first time
Researchers from TU Graz and acib succeed in the first enzyme-driven biocatalytic synthesis of nucleic acid building blocks. This facilitates the development of antiviral agents and RNA-based therapeutics. Due to the COVID 19 pandemic and the associated intensive search for therapeutics and vaccines, the chemical substance class of nucleosides is experiencing an enormous increase in interest.

Pharmacology - Health - 01.12.2020
Environmental exposures affect therapeutic drugs
Environmental exposures affect therapeutic drugs
High-resolution mass spectrometry promotes new methods for analysis Humans are exposed to various environmental or dietary molecules that can attenuate or even increase the effect of therapeutic drugs. Studies on the industrial chemical bisphenol A and the phytoestrogen genistein, for example, have shown drug-exposome interactions.

Pharmacology - Chemistry - 07.07.2020
Towards improved wound healing - Chemical synthesis of a trefoil factor peptide
Towards improved wound healing - Chemical synthesis of a trefoil factor peptide
Milestone for therapeutic development of peptides against gastrointestinal disorders The fascinating family of trefoil factor peptides brings hope to both research and industry to improve the treatment of chronic disorders such as Crohn's disease. For the first time, a team led by ERC awardee Markus Muttenthaler from the Faculty of Chemistry of the University of Vienna succeeded in the synthesis and folding of the peptide TFF1, a key player in mucosal protection and repair.

Health - Pharmacology - 21.04.2020
Milestone for the early detection of sepsis
Milestone for the early detection of sepsis
Researchers from Graz, Austria, are developing a ground-breaking method that uses biomarkers to detect sepsis 2 to 3 days before the first clinical symptoms appear. This can significantly increase the chances of survival in cases of blood poisoning by bacteria or fungi. Additional pictures for download at the end of the text Whether activating or silencing genes, breaking down defective cells or building new tissue, our body is constantly working to repair itself, even in cases of illness.

Pharmacology - Life Sciences - 04.11.2019
From cone snail venom to pain relief
From cone snail venom to pain relief
Conotoxins are bioactive peptides found in the venom that marine cone snails produce for prey capture and defense. They are used as pharmacological tools to study pain signalling and have the potential to become a new class of analgesics. To date, more than 10,000 conotoxin sequences have been discovered.

Chemistry - Pharmacology - 27.08.2019
A molecular
A molecular "Trojan Horse"
The research group of Nuno Maulide from the Faculty of Chemistry of the University of Vienna has, in cooperation with the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, achieved the synthesis of a potential immunosuppressive agent by modification of a naturally occurring compound.

Pharmacology - Chemistry - 04.03.2019
When changing one atom makes molecules better
Chemists in Vienna find a method to replace hydrogen with fluorine in organic molecules The development and improvement of pharmaceuticals plays the central role in the ongoing battle against human disease. Organic synthesis is the field that enables these developments as it offers the toolbox to diversify chemical structures.

Health - Pharmacology - 14.01.2019
Herbal antioxidants are becoming increasingly important
Herbal antioxidants are becoming increasingly important
Secondary plant compounds as an alternative to antioxidant vitamins and minerals The human organism is constantly exposed to so-called free radicals, which are a burden on the body. If they get out of hand, the result is oxidative stress, which can promote disease. While this has been treated in the past with the help of antioxidant vitamins and minerals, scientists are now increasingly turning to the use of phytochemicals, representing plant secondary metabolites.

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