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Health - Pharmacology - 13.05.2024
Limited efficacy of common local anaesthetic
Liposomal bupivacaine was launched on the market twelve years ago to provide long-lasting local control of pain. The medication is used as a local anaesthetic, particularly for orthopaedic operations. A research study by MedUni Vienna has now shown the limited effectiveness of the substance. The study has just been published in the journal "Anesthesiology", the peer-reviewed journal of the American Society of Anesthesiologists (ASA).

Health - Pharmacology - 02.05.2024
Immunotherapy for lung cancer effective even before surgery
Blocking "switches" of the immune system has revolutionized the treatment of patients with various metastatic cancers. In 2018, the discovery of this principle was recognized by the Nobel Prize in Medicine. An international research team has now shown that the simultaneous inhibition of two "immune switches", PD-1 and LAG-3, can lead to the killing of lung cancer cells after just a few weeks.

Pharmacology - Health - 29.04.2024
New phytocannabinoid discovered in sweet violet
New phytocannabinoid discovered in sweet violet
Cannabinoids are endogenous hormones or naturally occurring molecules found in various plants, most commonly known as THC (?9-tetrahydrocannabinol) in cannabis plants. The therapeutic potential of these compounds is the subject of intensive research, yet their psychoactive and addictive properties stimulate intensive debate.

Health - Pharmacology - 23.04.2024
Liver cancer: Molecular signalling pathway of tumour development decoded
Liver cancer: Molecular signalling pathway of tumour development decoded
As a malignant disease of the liver cells, hepatocellular carcinoma (HCC) is one of the main causes of cancer-related deaths. While the treatment options for this aggressive type of cancer remain limited, the incidence is increasing. A research team led by Latifa Bakiri and Erwin Wagner from MedUni Vienna's Clinical Institute for Laboratory Medicine has now described a molecular signalling pathway that plays a key role in the development of liver cancer, thereby identifying a potential new starting point for the development of therapeutic treatments.

Health - Pharmacology - 25.03.2024
Progress made in understanding Crohn’s disease
Crohn's disease is a chronic inflammatory bowel disease that is sometimes insufficiently controlled by immunosuppressive therapies with a subsequent need for surgical removal of affected bowel segments. By analysing draining mesenteric lymph nodes of affected small intestinal segments of patients who had required surgery, a research team led by Lukas Unger from MedUni Vienna identified immune responses that improve our understanding of the disease.

Health - Pharmacology - 22.03.2024
Cervical cancer: immunotherapy proven to improve prognosis
Cervical cancer: immunotherapy proven to improve prognosis
Since 1999, the standard treatment for locally advanced cervical cancer has consisted of external radiotherapy followed by chemotherapy and brachytherapy. As the prognosis for patients is still poor in many cases despite these measures, intensive research is being conducted into new options. In a large-scale clinical trial, an international team involving MedUni Vienna has shown that the immunotherapeutic agent pembrolizumab in combination with chemoradiotherapy leads to a statistically significant improvement compared to chemoradiotherapy alone.

Health - Pharmacology - 15.03.2024
New insights could improve treatment of liver fibrosis
Repeated or chronic liver injury, for example by viral hepatitis or alcohol consumption, triggers a complicated molecular process of scaring called liver fibrosis. Researchers at CeMM and MedUni Vienna have now succeeded in better understanding this process in a new study by examining gene activities at various stages of the liver disease.

Health - Pharmacology - 13.03.2024
New findings on the prevention of heart attacks and strokes
New findings on the prevention of heart attacks and strokes
Blockage of arterial blood vessels caused by atherosclerosis is largely responsible for heart attacks and strokes, which are the most common causes of death worldwide. The complex mechanisms that lead to pathological changes in the arteries are not yet fully understood. An international research team led by the Medical University of Vienna and the University Hospital of Würzburg has now made important progress in understanding this disease and identified potential new approaches for early detection and therapy.

Physics - Pharmacology - 11.03.2024
Can quantum computers help in the development of new drugs?
Can quantum computers help in the development of new drugs?
Scientists predict that quantum computers will be able to discover drugs faster than conventional computers in the future Quantum computers have promising potential applications. One potential area of application is computer-aided research and development of new drugs. A team from the University of Vienna, together with researchers from Boehringer Ingelheim, BASF, Google, QC Ware and the University of Toronto, have investigated the possibilities of this technology in a review article published in the journal Nature Physics .

Pharmacology - Health - 11.03.2024
Further developed COVID vaccine from MedUni Vienna shows promising results against Omikron
Researchers at the Center for Pathophysiology, Infectiology and Immunology at the Medical University of Vienna have further developed their Covid-19 vaccine, which has now shown promise in the fight against the Omikron variant of the virus. The results of their work were recently published in the top journal "Vaccines".

Health - Pharmacology - 15.02.2024
Chronic fatigue syndrome: number of patients is expected to double due to long-term effects of the COVID-19 pandemic
Up to 80,000 people in Austria are estimated to suffer from chronic fatigue syndrome, also known as ME/CFS or myalgic encephalomyelitis/chronic fatigue syndrome. The number of ME/CFS patients is expected to rise drastically due to long-term effects of the COVID-19 pandemic. However, research in the field has neither identified mechanisms of disease onset nor causal treatment approaches.

Health - Pharmacology - 14.02.2024
New treatment option for heart valve insufficiency
Severe heart disease or pulmonary hypertension often lead to a leak in the tricuspid valve, the valve between the right atrium and the right ventricle. However, tricuspid regurgitation can also occur without a clearly identifiable cause. In the past, this leakage was mainly treated with medication using diuretics and, for some years now, with clips inserted into the heart valve.

Pharmacology - Life Sciences - 05.02.2024
Exact mechanism of serotonin transport in nerve cells researched
Drugs known as antidepressants target the serotonin transporter in nerve cells and are among the most commonly prescribed medicines worldwide, but are sometimes associated with significant side effects. As part of a study, a research group led by Thomas Stockner from MedUni Vienna identified the basic principles of serotonin transport and thus created a possible basis for the development of novel drugs with improved selectivity and with fewer undesirable effects.

Health - Pharmacology - 29.01.2024
Coronary Stents: Acute inflammation triples the risk of thrombosis
Coronary Stents: Acute inflammation triples the risk of thrombosis
Coronary stents are implanted in more than 26,000 patients in Austria every year to treat angina pectoris or heart attacks. These are vascular stents made of metal that help to keep narrowed vessels open for many years. Acute clot formation (thrombosis) is the most feared complication of these procedures.

Health - Pharmacology - 23.01.2024
New therapeutic approach for the treatment of sarcoidosis
A research team led by Georg Stary (Medical University of Vienna and CeMM) has identified a new approach to treating the inflammatory disease sarcoidosis. In a clinical study, the inhibition of a specific signaling pathway showed clear success in the treatment of granulomas in the skin. This opens up new therapeutic paths for sarcoidosis and similar inflammatory diseases.

Health - Pharmacology - 17.01.2024
Kidney and heart diseases reduce survival rate after severe burns
Kidney and heart diseases reduce survival rate after severe burns
Despite enormous medical advances, severe burns are still potentially life-threatening injuries. Clinical scores, which take relevant parameters into account, are available to doctors as a decision-making aid for therapeutic measures and to assess the probability of patient survival. Pre-existing diseases were not previously included in these models.

Health - Pharmacology - 10.01.2024
Vaccine boosts innate immunity in people with dormant immune cells
Bacillus Calmette-Guérin (BCG) is one of the world's oldest and most widely used vaccines. It was developed in the early 20th century to provide protection from tuberculosis. Surprisingly, this vaccine protects not only against tuberculosis but also reduces the risk for various other infections, through a mechanism called trained immunity.

Health - Pharmacology - 09.01.2024
Survey shows skepticism towards generics and biosimilars among healthcare professionals in Vienna
A recent study by the Medical University of Vienna sheds light on the perception and knowledge of healthcare professionals regarding generics and biosimilars. A survey showed that there is still widespread skepticism and large gaps in knowledge about these medicines. The results were published in the European Journal of Clinical Pharmacology.

Health - Pharmacology - 12.12.2023
New study by Med Uni Graz on COVID-19 vaccination
New study by Med Uni Graz on COVID-19 vaccination
Sneezing on the bus, coughing on the streetcar, catching a cold at work - a record number of sick notes and wastewater analyses show an unprecedented viral load throughout Austria. The winter, and with it the new COVID-19 wave, has hit Austria hard. The virus, which has been keeping us on our toes since the beginning of 2020, is once again sweeping through the country, even if its progress is to be slowed down with the help of vaccinations and precautionary measures.

Pharmacology - Health - 06.12.2023
New approach to drug discovery: pain medication with fewer side effects developed
People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects. Accordingly, in recent years the search for safer alternatives has been the focus in drug discovery. As part of an international study led by MedUni Vienna, an opioid-like molecule has now been developed which, as shown in animal models, can effectively alleviate pain but with fewer undesirable side effects.
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