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Pharmacology - Health - 09:06
Health - Pharmacology - 02.10.2023
Health - 29.09.2023
Health - Pharmacology - 21.09.2023 
Small cell lung cancer: new approach to overcoming chemo-resistance
Small cell lung cancer accounts for about 15 percent of all diagnosed lung cancers and is still associated with a high mortality rate. SCLC tumours often develop resistance to chemotherapy and thus poor prognosis is due to tumour recurrence which occurs within only five to 14 months after initial diagnosis.
Health - Life Sciences - 18.09.2023 
New gut microbe produces smelly toxic gas but protects against pathogens
Taurine-degrading bacteria influence intestinal microbiome An international team of scientists led by microbiologist Alexander Loy from the University of Vienna has discovered a new intestinal microbe that feeds exclusively on taurine and produces the foul-smelling gas hydrogen sulfide. The researchers have thus provided another building block in the understanding of those microbial processes that have fascinating effects on health.
Health - Life Sciences - 18.09.2023
Health - Pharmacology - 18.09.2023
Health - 12.09.2023 
Extremely high risk of further fractures in osteoporosis sufferers
Bone fractures due to osteoporosis are a major risk for the elderly. It is therefore all the more important to identify people at risk. An international team of authors with the participation of scientists from Med Uni Graz has analyzed how high the risk is of suffering a second bone fracture after the first: The risk is almost 90 percent higher.
Health - Life Sciences - 07.09.2023 
Decoding Blood Platelet Production: The Intricate Role of Lipids
Disruptions in lipid metabolism might affect platelet production. Scientists unveiled a deeper understanding of megakaryocyte differentiation and blood platelet production, a process crucial for maintaining healthy blood clotting and preventing excessive bleeding. The study featured in "Nature Cardiovascular Research," led by chemist Robert Ahrends from the University of Vienna and cardiologist Oliver Borst from the University of Tübingen, sheds light on the intricate role of lipids - the building blocks of cell membranes - in the formation of these vital blood components.
Health - Pharmacology - 06.09.2023
Health - Pharmacology - 01.09.2023 
Gene Mutation in the Immune System: Anti-Diabetes Drugs Make Immune Cells More Effective Again
T cells are an essential component of the immune system - they fight foreign structures such as bacteria and viruses or cancer-related changes in cells. This defense reaction requires energy. Scientists led by the St. Anna Children's Cancer Research Institute, MedUni Vienna and the Marmara University Istanbul have now shown for the first time that a defect in the gene for the transcription factor NFATC1 leads to an immune defect with a disruption of metabolism in T lymphocytes.
Health - Life Sciences - 31.08.2023 
Targeting age-related diseases with biomarkers
Innsbruck researchers are making a major contribution to a new international concept for aging research. A new framework for so-called biomarkers makes it easier to define the biological process of aging. In this way, the researchers are also opening up new avenues for the prevention of age-related diseases.
Health - 24.08.2023 
Continuous blood glucose monitoring safe for pilots with diabetes
In recent years, permanent glucose measurement from tissue fluid has become established, especially for type 1 diabetics who are constantly dependent on insulin to control their blood glucose. According to the latest study by an Austrian-British-Irish research team, such a system is also safe for professional pilots .
Health - 22.08.2023 
New insights into fibrosis after myocardial infarction
After a heart attack, the healing process can lead to increased storage of connective tissue and thus to excessive scarring of the damaged heart muscle. This so-called fibrosis in turn leads to the heart muscle gradually becoming stiff and unable to work properly, which ultimately results in heart failure.
Health - 17.08.2023 
These are the most common allergens in hair dyes
Hair dyes can easily trigger contact allergies. In a large-scale project, the Information Network of Dermatological Clinics (IVDK) has investigated which substances are most frequently involved. The importance of hair dyes for allergies is thus evident. Safety at the workplace and product safety should be improved, the scientists involved now wrote in their study .
Health - Pharmacology - 14.08.2023
Health - Pharmacology - 09.08.2023
Health - Pharmacology - 31.07.2023 
New method selectively inhibits lactate transporters and creates new therapeutic approaches
A research group led by Giulio Superti-Furga of the Institute of Pharmacology at the Medical University and the CeMM Research Center has developed a new method that makes it possible to specifically inhibit important lactate transporters associated with cancer and numerous other diseases. This could provide a new starting point for the treatment of cancer in particular.
Health - 28.07.2023
Health - Pharmacology - 28.07.2023 
New method enabling therapeutical targeting of lactate transporters
Scientists from the Giulio Superti-Furga Lab at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, have developed a new method that allows the discovery of specific inhibitors of a lactate transporter associated with cancer and other disease areas. The compound identified in the assay system could provide a new starting point for cancer treatments.
Health
Results 1 - 20 of 257.
Prediction of the risk of recurrence of venous thrombosis - validity of the Vienna Prediction Model confirmed
A prediction model can be used to identify people affected by venous thromboembolism who have only a low risk of recurrence and may not require long-term blood thinning. The validity of this "Vienna Prediction Model" developed at MedUni Vienna has now been confirmed in a large-scale clinical study and the results have been published in the renowned European Heart Journal.
A prediction model can be used to identify people affected by venous thromboembolism who have only a low risk of recurrence and may not require long-term blood thinning. The validity of this "Vienna Prediction Model" developed at MedUni Vienna has now been confirmed in a large-scale clinical study and the results have been published in the renowned European Heart Journal.
Breakthrough in the fight against resistance in metastatic breast cancer
A team of researchers at the Medical University of Vienna has discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein called P-glycoprotein (P-gp). This discovery opens up new possibilities for delaying relapse and is particularly relevant for aggressive triple-negative breast cancer (TNBC), for which there are currently few effective treatments.
A team of researchers at the Medical University of Vienna has discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein called P-glycoprotein (P-gp). This discovery opens up new possibilities for delaying relapse and is particularly relevant for aggressive triple-negative breast cancer (TNBC), for which there are currently few effective treatments.
Atopic dermatitis: viruses discovered as new therapy option
Up to 15 percent of children and five percent of adults are affected by the chronic inflammatory skin disease atopic dermatitis. Despite advanced therapy measures, the severe itching and eczema, especially on the elbows or knees, cause great distress to the patients. In the course of a study conducted at MedUni Wien a research team led by Wolfgang Weninger, Head of the Department of Dermatology, has discovered a new approach: bacteriophages, which colonize the skin as viral components of the microbiome and can drive the development of innovative atopic dermatitis therapies.
Up to 15 percent of children and five percent of adults are affected by the chronic inflammatory skin disease atopic dermatitis. Despite advanced therapy measures, the severe itching and eczema, especially on the elbows or knees, cause great distress to the patients. In the course of a study conducted at MedUni Wien a research team led by Wolfgang Weninger, Head of the Department of Dermatology, has discovered a new approach: bacteriophages, which colonize the skin as viral components of the microbiome and can drive the development of innovative atopic dermatitis therapies.
Small cell lung cancer accounts for about 15 percent of all diagnosed lung cancers and is still associated with a high mortality rate. SCLC tumours often develop resistance to chemotherapy and thus poor prognosis is due to tumour recurrence which occurs within only five to 14 months after initial diagnosis.
Taurine-degrading bacteria influence intestinal microbiome An international team of scientists led by microbiologist Alexander Loy from the University of Vienna has discovered a new intestinal microbe that feeds exclusively on taurine and produces the foul-smelling gas hydrogen sulfide. The researchers have thus provided another building block in the understanding of those microbial processes that have fascinating effects on health.
Autoimmune diseases: Protein discovered as potential new target for therapies
Autoimmune diseases are complex conditions whose causes are diverse and have not been fully elucidated to date. A research team at MedUni Vienna has now discovered an immunoregulatory protein that could be linked to the development of autoimmune diseases such as rheumatoid arthritis. -Rinl- is the name of the identified building block of the immune system, which may provide a new starting point for the development of immunomodulatory therapies.
Autoimmune diseases are complex conditions whose causes are diverse and have not been fully elucidated to date. A research team at MedUni Vienna has now discovered an immunoregulatory protein that could be linked to the development of autoimmune diseases such as rheumatoid arthritis. -Rinl- is the name of the identified building block of the immune system, which may provide a new starting point for the development of immunomodulatory therapies.
Autoimmune diseases: Protein discovered as potential new target for therapies
Autoimmune diseases are complex illnesses, the causes of which are diverse and have not yet been fully explained. A research team at MedUni Vienna has now discovered an immunoregulatory protein that could be linked to the development of autoimmune diseases such as rheumatoid arthritis. The identified component of the immune system is called "Rinl", which could provide a new target for the development of immunomodulatory therapies.
Autoimmune diseases are complex illnesses, the causes of which are diverse and have not yet been fully explained. A research team at MedUni Vienna has now discovered an immunoregulatory protein that could be linked to the development of autoimmune diseases such as rheumatoid arthritis. The identified component of the immune system is called "Rinl", which could provide a new target for the development of immunomodulatory therapies.
Bone fractures due to osteoporosis are a major risk for the elderly. It is therefore all the more important to identify people at risk. An international team of authors with the participation of scientists from Med Uni Graz has analyzed how high the risk is of suffering a second bone fracture after the first: The risk is almost 90 percent higher.
Disruptions in lipid metabolism might affect platelet production. Scientists unveiled a deeper understanding of megakaryocyte differentiation and blood platelet production, a process crucial for maintaining healthy blood clotting and preventing excessive bleeding. The study featured in "Nature Cardiovascular Research," led by chemist Robert Ahrends from the University of Vienna and cardiologist Oliver Borst from the University of Tübingen, sheds light on the intricate role of lipids - the building blocks of cell membranes - in the formation of these vital blood components.
Cause of rapid loss of vaccination protection in autoimmune diseases identified
People who are treated with TNF-α inhibitors for their autoimmune disease such as Crohn's disease or rheumatoid arthritis lose their vaccination protection significantly earlier than average. The mechanism underlying the early decrease in antibody levels has now been eludicated by a scientific team from MedUni Vienna.
People who are treated with TNF-α inhibitors for their autoimmune disease such as Crohn's disease or rheumatoid arthritis lose their vaccination protection significantly earlier than average. The mechanism underlying the early decrease in antibody levels has now been eludicated by a scientific team from MedUni Vienna.
T cells are an essential component of the immune system - they fight foreign structures such as bacteria and viruses or cancer-related changes in cells. This defense reaction requires energy. Scientists led by the St. Anna Children's Cancer Research Institute, MedUni Vienna and the Marmara University Istanbul have now shown for the first time that a defect in the gene for the transcription factor NFATC1 leads to an immune defect with a disruption of metabolism in T lymphocytes.
Innsbruck researchers are making a major contribution to a new international concept for aging research. A new framework for so-called biomarkers makes it easier to define the biological process of aging. In this way, the researchers are also opening up new avenues for the prevention of age-related diseases.
In recent years, permanent glucose measurement from tissue fluid has become established, especially for type 1 diabetics who are constantly dependent on insulin to control their blood glucose. According to the latest study by an Austrian-British-Irish research team, such a system is also safe for professional pilots .
After a heart attack, the healing process can lead to increased storage of connective tissue and thus to excessive scarring of the damaged heart muscle. This so-called fibrosis in turn leads to the heart muscle gradually becoming stiff and unable to work properly, which ultimately results in heart failure.
Hair dyes can easily trigger contact allergies. In a large-scale project, the Information Network of Dermatological Clinics (IVDK) has investigated which substances are most frequently involved. The importance of hair dyes for allergies is thus evident. Safety at the workplace and product safety should be improved, the scientists involved now wrote in their study .
Research into use of diabetes medication for treatment of metastatic prostate cancer
Patients with localised prostate cancer have a good chance of survival, but mortality rates among those with advanced, metastatic forms of the condition remain high. Until now, the precise mechanism behind the spread of the tumour has not been fully explained. But an international research team headed by MedUni Vienna has succeeded in decoding the underlying cellular signal pathway and has carried out research using a common diabetes medication that could provide a new treatment option.
Patients with localised prostate cancer have a good chance of survival, but mortality rates among those with advanced, metastatic forms of the condition remain high. Until now, the precise mechanism behind the spread of the tumour has not been fully explained. But an international research team headed by MedUni Vienna has succeeded in decoding the underlying cellular signal pathway and has carried out research using a common diabetes medication that could provide a new treatment option.
Childhood cancer: ’New’ immune system responds better to therapy
Scientists at Medical University Vienna/St. Anna Children's Cancer Research Institute and the Eberhard Karls University of Tübingen have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children. Crucially, stem cells from a parent provide children with a new immune system that responds much better to immunotherapies.
Scientists at Medical University Vienna/St. Anna Children's Cancer Research Institute and the Eberhard Karls University of Tübingen have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children. Crucially, stem cells from a parent provide children with a new immune system that responds much better to immunotherapies.
A research group led by Giulio Superti-Furga of the Institute of Pharmacology at the Medical University and the CeMM Research Center has developed a new method that makes it possible to specifically inhibit important lactate transporters associated with cancer and numerous other diseases. This could provide a new starting point for the treatment of cancer in particular.
Skin cancer diagnosis: reinforcement learning for improved performance of artificial intelligence explored
Artificial intelligence (AI) is already being used to diagnose skin cancer, but it cannot (yet) keep pace with the complex decision-making of doctors in practice. An international research team led by Harald Kittler of MedUni Vienna has now explored a learning method in which greater accuracy in AI results can be achieved by incorporating human decision-making criteria.
Artificial intelligence (AI) is already being used to diagnose skin cancer, but it cannot (yet) keep pace with the complex decision-making of doctors in practice. An international research team led by Harald Kittler of MedUni Vienna has now explored a learning method in which greater accuracy in AI results can be achieved by incorporating human decision-making criteria.
Scientists from the Giulio Superti-Furga Lab at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, have developed a new method that allows the discovery of specific inhibitors of a lactate transporter associated with cancer and other disease areas. The compound identified in the assay system could provide a new starting point for cancer treatments.
