MicroRNA test: innovation to improve safety in liver surgery

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Researchers at MedUni Vienna have joined forces with the Viennese start-up TAmiRNA to develop a test that aims to improve the safety of liver surgery. The invention by Alice Assinger and Patrick Starlinger is based on the precise analysis of circulating microRNAs and is now ready for the market.

Postoperative liver failure remains the most common cause of death after liver resection. In particular, impaired liver function prior to surgery is considered a significant risk factor. Until now, however, there has been no precise method for objectively quantifying liver function. Researchers Alice Assinger and Patrick Starlinger were able to show that a specific combination of circulating microRNAs can predict liver function and the risk of liver failure far more accurately than existing clinical parameters.

In order to put these findings into practice, a CE-IVD-certified PCR test was developed. This enables a standardized determination of the relevant microRNAs and is the first test of its kind in Europe. "The technology was secured through patent applications by MedUni Vienna and TAmiRNA and a license agreement was concluded between the two partners; important steps towards the market launch of a new innovative product," says Andrea Kolbus from MedUni Vienna’s Technology Transfer department.

The market launch was supported by patent applications from MedUni Vienna and TAmiRNA as well as a license agreement between the two partners.

Establishment at renowned centers

The product is already being used in several medical centers, including Vienna General Hospital. "Our aim is to significantly improve safety in liver surgery and minimize the risks for patients worldwide," explains Alice Assinger. The use of the test at Vienna General Hospital marks an important milestone in the dissemination of this innovation.

Basic research with impact

The MicroRNA test impressively demonstrates how basic research can find its way from the lab bench to the bedside. "This It shows that bold questions and collaboration with a strong team can lead to groundbreaking results," emphasizes Patrick Starlinger.