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Health - Life Sciences - 10.04.2024
Key interaction of molecules discovered to influence hormone release
In a study recently published in the scientific journal PNAS, a research team led by MedUni Vienna has presented results that show a new way for drug development for post-traumatic stress disorder, alongside other indications. Although around four per cent of the population suffer from this mental illness, only symptomatic therapies are currently available.

Life Sciences - Health - 05.04.2024
The membrane that surrounds the embryo in the earliest stage of development
A MedUni Vienna study team led by geneticist Markus Hengstschläger has used a stem cell model to model the earliest stages of embryonic development and to characterize the membrane that surrounds the embryo, conferring shape and stability. This membrane is responsible for the specification and organization of the embryo's cells and allows it to grow in a controlled manner.

Life Sciences - Chemistry - 05.04.2024
Nerve Cells 'Old at Heart'
Nerve Cells ’Old at Heart’
April 5, 2024 New research shows: key molecules within nerve cells persist throughout life Most human nerve cells last a lifetime without renewal. A trait echoed within the cells' components, some enduring as long as the organism itself. New research by Martin Hetzer, molecular biologist and president of the Institute of Science and Technology Austria (ISTA), and colleagues discovered RNA, a typical transient molecule, in the nerve cells of mice that remain stable for their entire lives.

Health - Life Sciences - 28.03.2024
Cell research: New lysosomal dipeptide transporter described
In a recently published research paper, led by Marko Roblek from MedUni Vienna's Center for Physiology and Pharmacology, the function of a specific protein (SLC MFSD1) as a dipeptide transporter has been described for the first time. Dysregulation of MFSD1 is associated with liver disease, lymphocyte formation disorders and tumor metastasis, making these proteins highly relevant clinically.

Life Sciences - 28.03.2024
Neuronal circuit for reduced feeding at high temperatures decoded
When temperatures rise, appetite decreases: this can be observed after a winter sauna visit as well as on a midsummer day outdoors. There is scientific evidence that feeding is reduced when we are acutely exposed to heat. However, the exact reasons for this were previously unknown. An international research team led by MedUni Vienna has now described for the first time the neuronal signalling pathway that reduces feeding upon heat exposure.

Health - Life Sciences - 27.03.2024
Energy requirements for T cell functionality decoded
A research team led by Loïc Dupré (Department of Dermatology, MedUni Vienna) has conducted experiments to identify a coordinated molecular axis that governs the functionality of T cells. The study reveals how the availability of cellular energy controls the remodelling of the actin cytoskeleton, a central cellular activity that determines the ability of T cells to migrate and establish dynamic contacts.

Life Sciences - 18.03.2024
Genetic basis for the evolution of hair discovered in the clawed frog
The development of hair was of central importance for the evolution of mammals and thus also of humans. However, the evolutionary origin of the genetic programme of hair was previously unknown. An international research team led by Leopold Eckhart from MedUni Vienna has now been able to show that important hair components and their genetic control have already evolved in amphibians.

Life Sciences - Health - 29.02.2024
Significant progress in bionic reconstruction of limb functions
Significant progress in bionic reconstruction of limb functions
Bionic reconstruction, in which functionless limbs are replaced by mechatronic limbs, can restore mobility and quality of life to accident patients. However, the high-resolution transmission of information from the brain to the machine remains a demanding challenge. An interdisciplinary research team led by Vlad Tereshenko and Oskar Aszmann from MedUni Vienna's Department of Plastic, Reconstructive and Aesthetic Surgery has now made further significant progress as part of a study.

Health - Life Sciences - 27.02.2024
Immune system meets cancer: Checkpoint identified to fight solid tumors
Immune system meets cancer: Checkpoint identified to fight solid tumors
Checkpoint PHDGH in tumor-associated macrophages influences immune response and tumor growth A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in the top-class journal Cellular & Molecular Immunology , has a promising result from tumor research: The enzyme phosphoglycerate dehydrogenase (PHDGH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus on tumor growth.

Environment - Life Sciences - 23.02.2024
Global warming increases the diversity of active soil bacteria
Global warming increases the diversity of active soil bacteria
New findings enable more accurate prediction of the carbon cycle Warmer soils harbour a greater diversity of active microbes, according to a new study from researchers at the Centre for Microbiology and Environmental Systems Science (CeMESS) at the University of Vienna. The study, published in Science Advances , represents a significant shift in our understanding of how microbial activity in the soil influences the global carbon cycle and possible feedback mechanisms on the climate.

Life Sciences - Environment - 21.02.2024
Baleen whales evolved a unique larynx to communicate
Baleen whales evolved a unique larynx to communicate
The new results also make it clear that human noise in the oceans severely restricts the animals The iconic baleen whales, such as the blue, gray and humpback whale, depend on sound for communication in the vast marine environment where they live. However, ever since whale song were first discovered more than 50 years ago, it remained unknown how baleen whales produce their complex vocalizations - until now.

Life Sciences - Health - 15.02.2024
Neuronal Insights: Flash and Freeze-Fracture
Neuronal Insights: Flash and Freeze-Fracture
ISTA researchers analyze brain region using light flashes, high-pressure freezing and fracturing Fear and addiction exert significant influence within society. Managing them is often challenging, as they are driven by intricate neuronal circuits in our brains. Understanding the underlying molecular mechanisms is crucial to intervene when these processes malfunction.

Pharmacology - Life Sciences - 05.02.2024
Exact mechanism of serotonin transport in nerve cells researched
Drugs known as antidepressants target the serotonin transporter in nerve cells and are among the most commonly prescribed medicines worldwide, but are sometimes associated with significant side effects. As part of a study, a research group led by Thomas Stockner from MedUni Vienna identified the basic principles of serotonin transport and thus created a possible basis for the development of novel drugs with improved selectivity and with fewer undesirable effects.

Life Sciences - Chemistry - 05.02.2024
Down to the Core of Poxviruses
Down to the Core of Poxviruses
ISTA researchers uncover the architecture of poxvirus cores A recent re-emergence and outbreak of Mpox brought poxviruses back as a public health threat, underlining an important knowledge gap at their core. Now, a team of researchers from the Institute of Science and Technology Austria (ISTA) lifted the mysteries of poxviral core architecture by combining various cryo-electron microscopy techniques with molecular modeling.

Health - Life Sciences - 18.01.2024
Role of the GCP signalling pathway in ageing identified
With increasing life expectancy, old age is becoming an ever larger part of the human lifespan. During ageing, the way cells function changes, which sometimes has drastic consequences for the body. A recent study published in the journal "Nature Aging", led by Josef Penninger, Professor of Personalised Medicine at MedUni Vienna, reveals the crucial role of a previously unknown lipid metabolic pathway in ageing, in particular its impact on muscle health and glucose control.

Life Sciences - 16.01.2024
Do violent video games numb us towards real violence?
Do violent video games numb us towards real violence?
Results of a neuroscientific study suggest that violence in video games has no negative influence on the empathy of adults Neuroscientists from the University of Vienna and the Karolinska Institute in Stockholm have investigated whether playing violent video games leads to a reduction in human empathy.

Life Sciences - Health - 11.01.2024
Protein complex discovered to control DNA repair
The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team led by Christian Seiser from MedUni Vienna's Center for Anatomy and Cell Biology has now discovered a previously unrecognised control point for these processes.

Life Sciences - 11.01.2024
Synapses Brought to the Point
Synapses Brought to the Point
Scientists unravel structure and function of important inhibitory synapses in the cerebellum Whether picking up a small object like a pen or coordinating different body parts, the cerebellum in the brain performs essential functions for controlling our movement. Researchers at the Institute of Science and Technology Austria (ISTA) investigated how a crucial set of synapses between neurons within it functions and develops.

Health - Life Sciences - 10.01.2024
Possible trigger of chronic inflammatory bowel disease identified
As the cause of chronic inflammatory bowel diseases (IBD) such as Crohn's disease or ulcerative colitis is not yet known, treatment for sufferers is currently aimed at alleviating the often agonising symptoms. The discovery by a MedUni Vienna research team that the trigger for IBD could be found on the surface of intestinal epithelial cells provides a new potential starting point for the development of therapeutic measures.

Life Sciences - 09.01.2024
Stranger than Friction: A Force Initiating Life
Scientists examine how friction forces propel development in a marine organism As the potter works the spinning wheel, the friction between their hands and the soft clay helps them shape it into all kinds of forms and creations. In a fascinating parallel, sea squirt oocytes (immature egg cells) harness friction within various compartments in their interior to undergo developmental changes after conception.