Study led by TU Graz shows that apple trees inherit their microbiome to the same extent as their genes. The results lay the foundation for new breeding strategies for healthy and climate-robust fruit and vegetables.
Agriculture is facing enormous challenges worldwide due to global changes caused by human activities. Drought, severe weather events, record temperatures and emerging pathogens threaten the world’s food supply. For this reason we need to make our crops more robust without further polluting the environment. Microbiome research and management offer great potential to achieve these goals. A new study by an international research group led by Graz University of Technology (TU Graz), published in the scientific journal New Phytologist, opens up new perspectives here.
The importance of the microbiome for living organisms
Microbiome research is only a few decades old, but it has already produced some ground-breaking findings. One is that humans, animals and plants have very specifically adapted microbiomes that have taken over essential functions. Both organism and microbiome have evolved in co-evolution, i.e. in mutual influence. This was able to be confirmed by the present study. Today, we consider all organisms to be "holobionts" - jointly functioning units with numerous specialized microorganisms. The latter are always numerically superior; humans, for example, have ten times more microorganisms than their own cells. The microbiome is thus classified as an important target for new health therapies and prophylaxis. This is equally true for cultivated plants, but the potential here has so far been little known or exploited.
Confirmation of the coevolution theory
The interdisciplinary group of researchers compared the microbiome of modern domesticated apple crops - i.e. specifically bred and cultivated varieties - with the microbiome of their wild ancestors as well as with the microbiome of closely related species. With the help of molecular analyses and bioinformatic methods, the group was able to determine for the first time that the microbiome is inherited to the same extent as the genes. Apples that are genetically similar thus also harbour a similar microbiome. And surprisingly, our modern apple varieties still contain some of the microbiome of their wild ancestors.
The study shows that the microbiome is also "bred" and has greatly changed over time. Until now, this has happened unintentionally and many microorganisms have been lost in the process. These lost microorganisms could now help us to make our crops fit for climate change again. This is because the focus of breeding now is no longer on the size and sweetness of the apples, but on their resilience and health. The research group is convinced that the microbiome of the wild ancestors originating from the Inner-Asian Tien Shan mountain range contains valuable microorganisms for this purpose.
Publication: Evidence for host-microbiome co-evolution in apple Ahmed Abdelfattah, Ayco J.M. Tack, Birgit Wasserman, Jia Liu, Gabriele Berg, John Norelli, Samir Droby, Michael Wisniewski.
New Phytologist, DOI: 10.1111/nph.17820
Useful research results for agriculture
For the first author in the study, Ahmed Abdelfattah from the Institute of Environmental Biotechnology, "the results clarify a long scientific debate and lay the groundwork for new ecological strategies in plant breeding."
It would be conceivable, for example, to change the plant microbiome through the targeted introduction of microorganisms in order to increase the resistance of the plants. This is what the Institute of Environmental Biotechnology at TU Graz specializes in and Marie Curie Fellow Ahmed Abdelfattah specifically chose it as a research location due to its expertise in the field of microbiome biotechnology. "My apple microbiome journey started during my visit, as PhD candidate, to Dr. Michael Wisniewski’s lab in 2015", Abdelfattah says. Wisniewski, the last author of the article and the research with whom the original experiment was designed, is a professor at Virginia Tech with a long-established scientific contribution to fruit research.
In Graz again, the vision of Institute head Gabriele Berg and her team is to use this new knowledge for plant health as well as for that of humans and our planet. The apple is thus only a symbol, as it has been many times in human history.
This research area is anchored in the Field of Expertise " Human & Biotechnology ", one of the five research foci of TU Graz. The work was funded equally by the European Union’s Horizon2020 under ’Nurturing excellence by means of cross-border and cross-sector mobility’ program for MSCA-IF-2018-Individual Fellowships, g rant agreement 844114 and by BARD, Israel-US Binational Agricultural Research and Development Fund (IS-5040-17).
Institute of Environmental Biotechnology, Graz, Austria.
Department of Ecology, Environment and Plant Sciences, Stockholm, Sweden
Chongqing Key Laboratory of Economic Plant Biotechnology, Chongquing, China
Institute for Biochemistry and Biology, Potsdam, Germany.
Department of Postharvest Science, Agricultural Research Organization, Rishon LeZion, Israel