Figure 1: (Left:) Differences in structure prediction and de novo protein design. (Right:) Illustrative representation of protein sequence space (grey). Sequence analysis of native proteins shows that tight clusters of protein families can be identified (beige).
Computational design of novel protein structures is a promising tool to make superior biological materials with tailor-made properties, new pharmaceuticals or complex fine chemicals. Figure 1: ( Left: ) Differences in structure prediction and de novo protein design. Right: ) Illustrative representation of protein sequence space (grey). Sequence analysis of native proteins shows that tight clusters of protein families can be identified (beige) . Over the last two years research in my group focused on developing methods to design and functionalize de novo proteins. Ultimately, we are aiming to be able to routinely and robustly design catalytic or small molecule binding proteins of arbitrary shapes. DE NOVO PROTEIN DESIGN.
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