Gerhard Schütz
Neurotransmitter transporters are some of the most popular transport proteins in research as they play a major role in the processing of signals in the brain. A joint study by TU Wien and the Medical University of Vienna has now successfully demonstrated for the first time the structural impact of membrane lipids on medically relevant serotonin transporters. Hohe PIP2 Konzentrationen an der Zellmembran (links) verhindern SERT Oligomerisierung oder Dissoziation, sodass der Oligomerisierungsgrad arretiert wird. Im Endoplasmatischen reticulum ist die PIP2 Konzentration sehr gering (rechts), sodass die SERT-Oligomerisierung einem Gleichgewicht zustrebt. The membrane of a cell is composed of a lipid bilayer. Lipids are good chemical and electrical insulators, which are ideally suited to separating the inside of the cell from the outside of the cell. But membranes also harbour a large number of proteins, some of which regulate the controlled exchange of substances across the membrane.
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