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Postdoctoral and PhD position – Pathogen-phagocyte inter-kingdom signaling

University of Zürich
Institute of Medical Microbiology

Closing Date
WorkplaceZürich, Gloriastrasse 30, Zurich region, Switzerland
Duration2-4 Jahre
Occupation rate
Job StartJuly 1st 2021, or per agreement

The University of Zürich is an academic research and teaching institution of international standing.


The environmental bacterium Legionella pneumophila causes a severe pneumonia termed Legionnaires’ disease in humans and forms a unique replication-permissive vacuole in amoebae and macrophages. Pathogen-host cell interactions are governed by more than 300 different secreted bacterial "effector" proteins as well as by a small signaling molecule called LAI-1 (Legionella autoinducer-1). LAI-1 promotes inter-bacterial communication (quorum sensing) as well as prokaryote-eukaryote trans-kingdom signaling.
The project funded by the Swiss National Science Foundation aims at elucidating Legionella-phagocyte trans-kingdom signaling through LAI-1. To study the production, secretion, delivery, cellular targets and mode of action of LAI-1, the successful applicants will use a broad range of techniques in the disciplines Microbiology (handling of BL-2 pathogens, infection analysis, bacterial genetics), Cell Biology (confocal fluorescence microscopy, flow cytometry, RNA interference) and Biochemistry (FPLC/HPLC, protein-ligand interactions, purification of Legionella vacuoles).


Highly motivated individuals with an interest and background in Microbiology, Cell Biology, Biochemistry or a related area are invited to apply.

We offer

The positions (up to 4 years) are available at the Institute of Medical Microbiology, University of Zürich main campus, as of July 1st 2021, or upon mutual agreement.

Contact and Address

Please send your CV with a motivation letter and the contact details of 2 references as a single pdf file to Prof. Dr. Hubert Hilbi (hilbiimm.uzh.ch). For further information please contact Hubert Hilbi and visit our website (https://www.imm.uzh.ch/de/research/experimental/Hilbi.html).



044 634 2650


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