Results 1 - 20 of 24.

Health - Pharmacology - 17.11.2022
Obesity: research focuses on treatments for secondary diseases
As the number of obese people suffering from related conditions such as liver disease increases, so does the need for research to develop interventions to improve patient care. The Christian Doppler Laboratory, which opened today at MedUni Vienna, is investigating the physiological basis of the consequences of obesity.

Pharmacology - Health - 15.11.2022
Potential new lead compounds for the treatment of depression and anxiety disorders
Potential new lead compounds for the treatment of depression and anxiety disorders
Currently, various classes of drugs are available for the treatment of mental illnesses - such as depression and anxiety disorders. However, although these drugs confer benefits, they are also associated with adverse side-effects. Conseqeuntly, medical researchers continuously thrive to improve the pharmacological properties of therapeutic agents to optimize the benefit-to-side-effect ratio.

Health - Pharmacology - 25.08.2022
New drug expands treatment opportunities for rheumatoid arthritis
In its final Phase III clinical trial, a new drug for treating rheumatoid arthritis has proved to be at least as effective as the current "gold standard" treatment for this autoimmune disease. This opens up new treatment options for affected patients. The results of the international multicentre study led by MedUni Vienna were recently published in the prestigious "New England Journal of Medicine".

Pharmacology - Health - 22.06.2022
Mugwort allergy: MedUni Vienna study creates basis for vaccine
A research team at MedUni Vienna has discovered key mechanisms of allergy to pollen from the common weed mugwort, thereby also laying the foundation for the development of the world's first vaccine. Mugwort (Artemisia vulgaris) poses a serious problem for allergic individuals in our latitudes from July through to September.

Health - Pharmacology - 21.06.2022
New blood biomarker identified for status of fatty liver disease
New blood biomarker identified for status of fatty liver disease
A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease. As part of the immune system, these cells have a protective function against fibrosis and liver cirrhosis. At the same time, they are useful as biomarkers of liver disease progression as they can be measured by a blood test.

Health - Pharmacology - 15.06.2022
Covid-19: chronic liver disease patients at high risk of liver failure and bile duct damage
Patients with chronic liver disease may suffer hepatic complications as a result of severe Covid-19. A study conducted by a research team led by Lukas Hartl, Thomas Reiberger and Michael Trauner from the Division of Gastroenterology and Hepatology of MedUni Vienna and University Hospital Vienna found that a rise in cholestasis parameters and subsequent damage to the bile ducts, so-called secondary sclerosing cholangitis (SSC), develops with striking frequency in patients with pre-existing liver disease.

Health - Pharmacology - 03.06.2022
Consistently high willingness to receive an annual COVID-19 booster vaccination
Consistently high willingness to receive an annual COVID-19 booster vaccination
In view of the constant emergence of new viral variants and the limited duration of immune protection through recovery or vaccination, it is becoming increasingly likely that an annual COVID-19 booster vaccination might be needed. Working with colleagues from the Transatlantic Research Lab on Complex Societal Challenges, Jakob Weitzer and Eva Schernhammer from the Department of Epidemiology at the Medical University of Vienna and Gerald Steiner from the University of Continuing Education Krems investigated the willingness of the population to be vaccinated annually against COVID-19.

Life Sciences - Pharmacology - 24.05.2022
Molecular light switches provide insights into the central nervous system
Fluorescent dyes, such as those used in discotheques with black lights or from forensic crime-scene searches for blood traces, play an important role in pharmaceutical research in particular. They can be used to visualize biological structures in fluids, cells or tissues. A team led by neuropharmacologist Margot Ernst from the Medical University of Vienna and theoretical chemist Leticia González from the University of Vienna have conducted a study to investigate the mechanism of a fluorescent dye for neuroscience.

Health - Pharmacology - 19.05.2022
New non-invasive method of risk assessment in liver disease
In a recent study, an interdisciplinary research team from MedUni Vienna showed that functional magnetic resonance imaging (fMRI) can be used as a non-invasive method for predicting complications in chronic liver disease. The scientists combined a simple risk stratification system developed at MedUni Vienna - the functional liver imaging score (FLIS) - with splenic diameter.

Health - Pharmacology - 19.04.2022
New therapeutic option for head and neck carcinomas
The various manifestations of head and neck carcinomas rank sixth in frequency worldwide and are fatal for about half a million people every year. In a quarter of cases, head and neck squamous cell carcinoma (HNSCC) is caused by human papillomavirus (HPV) and, currently, is not always treatable. A research team led by Lorenz Kadletz-Wanke from MedUni Vienna's Department of Otorhinolaryngology and Head and Neck Surgery has now discovered a new therapeutic option in the context of a study.

Health - Pharmacology - 14.04.2022
Blood group as a marker for thrombosis risk in cancer patients
Blood group as a marker for thrombosis risk in cancer patients
A MedUni Vienna study found evidence that people with cancer and non-O blood group such as A, B or AB are at increased risk of developing venous thromboembolism (VTE), blood clots in the veins. The study was recently published in the journal "Blood Advances". VTE includes deep vein thrombosis (DVT), a blood clot that typically forms in the deep veins of the leg, and pulmonary embolism (PE), a life-threatening condition that occurs when a blood clot breaks free and lodges in the pulmonary arteries of the lungs.

Health - Pharmacology - 12.04.2022
Omicron: Number of vaccine breakthroughs in cancer patients on the rise
For cancer patients, Covid-19 poses a particular risk due to their often compromised immune systems, weakened by therapy or disease, which is why vaccination is very important for their protection. Now, a recent study led by MedUni Vienna shows that, due to Omicron, there is an increasing number of breakthrough infections in people with cancer, especially while they are undergoing cancer therapy.

Health - Pharmacology - 05.04.2022
Newly developed COVID vaccine from Austria could protect against omicron and other variants
The preclinical data for a vaccine developed at MedUni Vienna to protect against SARS-CoV-2 indicates that it is effective against all SARS-CoV-2 variants known to date, including omicron - even in those who have not yet built up any immunity as a result of vaccination (non-responders). The data from the study were recently published in the leading journal "Allergy".

Environment - Pharmacology - 15.02.2022
Pharmaceutical residues in the Vienna Danube
Pharmaceutical residues in the Vienna Danube
Pollutant concentrations in rivers provide a chemical fingerprint of society Residues of pharmaceuticals, cosmetics and lifestyle substances enter rivers via wastewater. A recent study shows that the concentration of such trace pollutants in the Vienna Danube is surprisingly high compared to other EU countries.

Health - Pharmacology - 22.12.2021
Covid-19 Infections in Nursing Homes: Simulation model for optimal prevention and vaccination strategies
Covid-19 Infections in Nursing Homes: Simulation model for optimal prevention and vaccination strategies
Researchers from TU Graz and Complexity Science Hub (CSH) Vienna have developed a detailed epidemiological model for the spread of the coronavirus in nursing homes. This enables optimal prevention strategies to be identified, as practical experience in Caritas nursing homes has shown. Since the beginning of the coronavirus pandemic, residents of nursing homes have been particularly at risk.

Health - Pharmacology - 03.12.2021
The role of bitter receptors in cancer
The role of bitter receptors in cancer
Bitter taste receptors do not only support humans in tasting. They are also found on cancer cells. A team led by Veronika Somoza from the Faculty of Chemistry at the University of Vienna and the German Leibniz Institute for Food Systems Biology at the Technical University of Munich has investigated the role they play there.

Pharmacology - Health - 08.03.2021
Psoriasis: study lays foundation for new treatment strategy
The precise choice of treatment for breast cancer depends upon the status of the hormone receptors (for oestrogen and progesterone). Their conventional determination by means of immunohistochemistry (IHC) is associated with a certain error rate, which can be reduced by adding genomic data. Even conventional statistics can bring about a notable improvement but now it is possible to use decision theory to optimally combine diagnostic findings, particularly where they are contradictory.

Pharmacology - Health - 09.02.2021
The therapeutic potential of peptides
The therapeutic potential of peptides
Currently there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis.

Pharmacology - Health - 01.12.2020
Environmental exposures affect therapeutic drugs
Environmental exposures affect therapeutic drugs
High-resolution mass spectrometry promotes new methods for analysis Humans are exposed to various environmental or dietary molecules that can attenuate or even increase the effect of therapeutic drugs. Studies on the industrial chemical bisphenol A and the phytoestrogen genistein, for example, have shown drug-exposome interactions.

Pharmacology - Chemistry - 07.07.2020
Towards improved wound healing - Chemical synthesis of a trefoil factor peptide
Towards improved wound healing - Chemical synthesis of a trefoil factor peptide
Milestone for therapeutic development of peptides against gastrointestinal disorders The fascinating family of trefoil factor peptides brings hope to both research and industry to improve the treatment of chronic disorders such as Crohn's disease. For the first time, a team led by ERC awardee Markus Muttenthaler from the Faculty of Chemistry of the University of Vienna succeeded in the synthesis and folding of the peptide TFF1, a key player in mucosal protection and repair.

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